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You have no real control over whether or not you take damage, as all enemies attack the Punching Bag rather than you. Oh, and the Punching Bag is the one that takes damage, not the heart. You must protect Isaac's Heart which isn't following you, but rather the Punching Bag that wanders around the room.
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What makes this worse is that you're playing as ?/Blue Baby, making it more difficult to recover health, and you have to fight all the way to the Chest. You're not only blindfolded, but your only offensive weapons are three Bob's Brains, which is a Scrappy Weapon infamous for its tendency to blow up right in your face. The Brains! challenge, again in Afterbirth.
BINDING OF ISAAC SPEED! PATCH
It's basically saying "reload until you get Brimstone or something else that kill instantly, otherwise you lose." A patch eventually increased Isaac's movement speed as well, making the challenge slightly more manageable in that you'll at least be able to outrun most enemies that chase you. Oh, and if you don't finish all the way to It Lives in under 16 minutes, you get half a heart of damage every few seconds which can kill you! It goes to the point it's almost impossible to even beat the first floor if you get a hard boss unless you get a good start. can move twice as fast and become practically unavoidable. There's Treasure Rooms, but that's little comfort when bosses like Gurdy Jr. Enemy movement and bullet speed are dialed up significantly while you start as basic Isaac. Repentance alleviated the challenge a bit as Brother Bobby and Sister Maggy received buffs, but it's still a tough experience. It's borderline impossible to complete the challenge without resorting to resetting until you can get a Cube of Meat or Ball of Bandages on the first floor. Thankfully, one of them is Rotten Baby, which scales with your damage, but other than that, you're gonna have a very hard time trying to damage enemies even a little bit. You're blindfolded, and your only means of damage are through three familiars. The Family Man challenge is probably the the hardest of the base game.Have fun playing the entire game with exploding tears that boomerang right back in your face! The Suicide King challenge in Rebirth.